Cancun vacations by Destinology. Mexico’s most popular resort is located on the Yucatan Channel that separates the country from the island of Cuba in the Greater Antilles. Cancun vacations give rise to a coastal city in the state of Quintana Roo featuring both old and new parts to reflect the effect tourism has had on this relatively young city. There is something for everyone here, from an all-day fun party beach to isolated, tranquil island ruins. Walk along the white sand beaches flanked by the warm waters of the Caribbean Sea, and take in the nightlife afterwards with the busy bars, malls, restaurants and nightclubs.